Another consequence when considering a gene therapy approach for a disorder such as DMD is that because a majority of the diseased cells have to be transduced in order to have a therapeutic benefit, whole-body AAV transduction of muscle requires the injection of very large amounts of vectors.
A majority of the diseased Dachshunds were classified as ISACHC 2 (79), followed by ISACHC 1 (60).
This means that the effect is required to have an all-or-none effect in the vast majority of exposed and diseased individuals.
Eight of 10 intestinal strains were non- invasive including the C. pecorum strains, while the majority of strains from diseased hosts, including C. abortus, successfully colonised the placenta and foetuses of pregnant mice [ 33].
Together they examined hundreds of bodies, and restored to health the great majority of their French-diseased patients.
A majority of down-regulated genes in diseased plants were genes whose expression levels decreased strongly in wilting plants but remained unaffected in healthy resistant plants (Figure 2B).
We have shown constitutive expression of NGF within 100% of IVD samples tested, although as the majority of the samples are from diseased tissues this is perhaps not surprising.
Thus, if the majority of the target population is diseased (1 - P = r < 0.5), classification errors with respect to healthy individuals are valued as more costly; if prevalence is low (1 - P = r > 0.5), classification errors with respect to diseased individuals are valued as more costly.
In the vast majority of cases, ECFs arise from the diseased distal ileum and are associated with long-standing or active fistulising CD; exceptionally, an ECF may be the initial manifestation of an undiagnosed IBD.
In a society in which the dominant religion excoriated homosexuality as a heinous sin, the law branded it a vicious crime, and the medical profession diagnosed homosexuals as diseased, the vast majority of individuals who harbored homosexual impulses did their best to hide their secret shame from family, friends, neighbors, employers, and associates.
