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Exact(6)
The majority of deregulated genes in Smyd2 cKO hearts displayed reduced expression.
In our analysis, a majority of deregulated genes showed a fold change that varied from 0.4 to 1.6, except for two genes, Klk6 (fold change=1.70, P<0.001) and Myoc (fold change=2.49, P<0.001).
Analysis of cohesin/CTCF binding at or near the TSSs of deregulated genes showed that the majority of deregulated genes do not have a cohesin/CTCF binding site within 10Kb of their TSS, however there was an enrichment for cohesin/CTCF binding at distances <10Kb from the TSS, suggesting that some but not all of the responding genes are direct targets for cohesin/CTCF-mediated gene regulatory loops.
A great majority of deregulated miRNAs are involved in mitochondrion-mediated apoptosis.
Time-series expression analyses resulted in clustering of the majority of deregulated transcripts into eight statistically significant expression profiles.
It is interesting to note that we were unable to identify high-affinity EREs on the majority of deregulated genes (65%) associated with a positive ER α status.
Similar(54)
The large majority of the deregulated transcripts were expressed by Sertoli cells (SCs) and Leydig cells (LCs).
Furthermore, we confirmed that the majority of the deregulated miRNAs were down-regulated in patients' blood cells.
Indeed, in a conditional transgenic mouse model overexpressing Lmnb1 in oligodendroglia, the majority of the deregulated genes are involved in typical oligodendrocyte functions, such as the formation and maintenance of myelin (12).
So is this yet another example of deregulated markets failing?
Inhibitors of deregulated kinases are effective small molecule anticancer drugs.
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