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The majority of depressed participants had mild symptoms (BDI 11 15); only 36% of participants with depression symptoms (2.7% of the overall cohort) had more severe depression symptoms (BDI score of ≥16), limiting our power to conduct subset analyses on the most severely depressed (likely major depressive disorder) participants.
They found that SSRIs did not help the vast majority of depressed people much more than placebos did.
With meticulous diagnosis, diligent monitoring and adjunctive psychotherapy, carefully selected antidepressants do far more good than harm in the vast majority of depressed adults and children.
The majority of depressed people suffer from insomnia, but there are some who instead experience constant sleepiness and fatigue.
The majority of depressed patients were referred to mental health care.
The vast majority of depressed inpatients receive pharmacotherapy, but receive psychotherapy less frequently [ 8- 10].
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The majority of the depressed women mentioned mental symptoms when they visited the GPs' drop in clinic.
Considering that the majority of prescriptions for antidepressants are written by physicians other than psychiatrists, and that a minority of depressed patients are also receiving psychotherapy, the potential economic impact of these recommendations is prohibitive.
Second, the majority of studies utilized non-depressed control groups which were nonetheless composed of individuals who met criteria for other psychiatric conditions.
Aversive stimuli such as air puffs, hypertonic saline and electric shock induce activating ('excitatory') responses in a small proportion of dopamine neurons in awake animals (14% [ 33]; 18-29% [ 44]; 23% [ 45]; 11% [ 46]), and the majority of dopamine neurons are either depressed in their activity or not influenced by aversive events.
However, the majority of studies either made no explicit attempt to characterize (let alone control for) the possible comorbid status of depressed participants, or when comorbidities were determined simply defaulted to major depression as the primary diagnosis.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com