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The majority of compounds displayed potent CXCR4 binding affinity.
This double protection means the vast majority of compounds cannot be absorbed into the body through the skin.
The majority of compounds were effective in the MES or/and scPTZ screen.
Majority of compounds displayed varying degrees of α-glucosidase inhibitory and DPPH scavenging activity.
Experimental measurements showed good agreement between predicted and measured activities for majority of compounds.
However, for the majority of compounds values obtained were below 1 μg/L (LOD) and 5 μg/L (LOQ).
The results indicated the majority of compounds 8a n displayed moderate to good inhibitory activities against PDE4CAT.
The pharmacological results revealed that the majority of compounds were effective in electrical (MES) and/or pentylenetetrazole induced seizure (scPTZ) models.
It may be inferred from the present data that majority of compounds in this series exhibit higher selectivity index than TBZ.
Despite several approved animal models, the majority of compounds tested successfully in animals still fail to be successfully applied to human diseases.
Inter-day and inter-twister precisions ranged from 0.22% to 19.01% and from 0.69% to 14.76% respectively, and values below 10% were obtained for the majority of compounds.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com