The vast majority of circulating cancer cells don't do anything.
"The vast majority of circulating DNA is from normal, non-cancerous cells, even in patients with advanced cancer," Bratman said.
While immune memory is generally associated with protective immune response to pathogens, memory T cells can be generated to diverse types of antigens including autoantigens and alloantigens through homologous or crossreactive priming and comprise the majority of circulating T cells during adulthood.
During sepsis, the vast majority of circulating leucocytes are neutrophils, with hardly any circulating monocytes, because these are known to migrate out of the circulation.
CONCLUSIONS: Our results show that the preexisting compensatory amino acids in the majority of circulating HIV-1 strains could significantly compromise the fitness loss due to CTL escape mutations and thus increase challenges for T cell based vaccines.
Experimental vaccine antigens based upon the HIV-1 envelope glycoproteins (Env) have failed to induce neutralizing antibodies (NAbs) against the majority of circulating viral strains as a result of antibody evasion mechanisms, including amino acid variability and conformational instability.
Female mice treated with ovariectomy (OVX), and a resulting depletion of the majority of circulating estrogens, have increased fat accumulation in the liver than the pair-fed sham operation mice (Shen and Shi, 2015).
The majority of circulating testosterone in the body is bound to SHBG, thus one would expect to see opposite changes in levels of these two hormones.
We assessed factors influencing HIV-1 Env CD8+ T cell epitope recognition in a large Kenyan population, where clade A1 comprises the majority of circulating sequences.
Furthermore, we assume that the vast majority of circulating immunoglobulin is produced by plasma cells with a very small fraction from B cells.
The availability of a broad-spectrum antiviral therapy that would be effective against the majority of circulating strains regardless of the susceptibility would be of high clinical utility.
