During embryonic development and fracture repair the majority of bone is formed indirectly from a cartilage intermediate in a process called endochondral ossification.
While the majority of Bone Sharps is true and all of it is based on history, the author acknowledged several differences between real events and certain artistic license taken.
As androgen receptors are expressed and presumingly active in a majority of bone metastases in CRPC [14], androgen actions probably contribute to the higher cholesterol levels in PCa metastases as compared to bone metastases of different origin.
Even at blast counts less than 5 percent, clonal cells are detected using the SNP peak height skewing data, implying that the majority of bone marrow cells may be clonal even when samples have low bone marrow myeloblast counts (Figure 2).
Although it did appear that the majority of bone marrow from TET-GFP mice did respond appropriately in response to doxycycline (gradual reduction in GFP+ cells over time), GFP+ cells could still be detected in whole bone marrow at a frequency of about 1.6% after 12 weeks of dox.
The vast majority of bone marrow cell types showed a tight regulation of GFP in response to dox treatment which poses the question of why the HSC population relatively specifically showed aberrant GFP expression in the absence of the tTA protein.
The majority of bone uptake occurs on the first pass of the ion through the circulation.
The great majority of bone metastases occur in red marrow regions where blood flow is high.
Gram-positive organisms, particularly S. aureus, are responsible for the majority of bone and joint infections.
