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However, the majority of bile acids that are not absorbed in the ileum are believed to undergo deconjugation and dihydroxylation by colonic microbiota, leading to the formation of secondary bile acids: deoxycholic acid and lithocholic acid.
The majority of bile acids are reabsorbed in the distal ileum, largely accomplished by an apical sodium dependent bile acid transporter, and thus ileal resection could explain the reduced bile acid absorption in ICD patients.
The majority of bile salts are conjugated in the liver to glycine or taurine, which increases their polar surface.
In contrast, when using a hard core, most models included a majority of bile acid reactions (60%~80% of pathway reactions), conflicting with known tissue specificity.
Secondly, the majority of bile acids are reabsorbed from the small intestine and return to the liver via the portal vein, where they are taken up by hepatocytes and re-secreted into bile [ 32].
A majority of bile duct injuries detected postoperatively were discovered as bile leakage, either from the cystic duct (46%) or from small ducts in the liver bed (18%), whereas only 142(2%) injuries with delayed detection were classified as severe.
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The majority of the bile acids are then returned to the liver via the portal circulation through ASBT (apical sodium-dependent bile acid transporter) in the epithelial cells of the small intestine.
In the vast majority of cases, bile collections are successfully managed without surgery, often with percutaneous drainage (Fig. 8) until spontaneous closure of leakage occurs [5, 8].
Although the majority of the bile acids is reabsorbed and reused a small fraction (1 4%) is not reabsorbed and passes into the colon [ 2].
The occurrence of the aberrant NPP7 from the 1.2 kb mRNA in the majority of the bile samples is not a finding we expected, but interesting.
Concomitant with this, it was found that the majority of BSEP (bile salt export pump) was retained in intracellular pools rather than localized to the canalicular membrane in hepatocytes from LLKB1KO (liver-specific Lkb1-knockout) mice.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com