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The observed change in gene expression was dose dependent for the majority of altered genes.
In pathway analysis, the majority of altered genes were involved in cell cycle/DNA repair (P <0.001) and cAMP-dependent protein kinase signaling (P <0.001).
A large majority of altered genes code for proteins that are involved in receptor tyrosine kinase (RTK) signaling, leading to the promotion of NSCLC cell proliferation, survival, migration, and invasion (Table 1) [9–13].
Further, the majority of altered proteins were unique to each confounder model, demonstrating biological specificity.
The majority of altered sites showed modest fold changes.
The majority of altered features were not previously observed, suggesting the formation of new molecules at high temperature.
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Splicing analysis identified ∼350 genes with significant (P < 0.001) changes in splice site representation (Supplementary Table S3, independent verification in Supplementary Fig S3); however, the majority of transcripts altered in splicing were not altered in abundance compared to wild-type.
The majority of metabolites altered in HIV subjects with HCV co-infection were also altered in subjects without HCV including sulfated steroids, bile acids, essential fatty acids (EFA), LCFA, fibrinogen cleavage peptides, and tryptophan metabolites.
The vast majority of genes altered in response to ISO treatment or swimming were specific to the condition (that is, there was relatively little overlap in the types of genes altered under these two conditions).
The majority of these altered pathways were increased (40), while only 5 were decreased (Fig. 10).
However, whatever the condition, a majority of the altered genes were involved in various aspects of lipid metabolism, as well as other functions, including glucose, cholesterol and bile acids and amino acid metabolisms, chemical biotransformation, inflammation or immunity (Table 4).
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