Sentence examples for majority of alterations from inspiring English sources

105 The great majority of alterations are single base substitutions (about 90%), with a prevalence of missense changes (60%, Figure 2).

Age-related gene changes in adipocytes fell into several categories of biological function including inflammatory response, genetic disorder and cellular development, whereas the majority of alterations of genes in both adipocyte depots were associated with mitochondrial dysfunction and lipid metabolism.

The large majority of alterations in chromatin structure we observed indicate an increase in marks associated with transcriptional repression at Day-7, yet our candidate genes demonstrated an increase in expression at this time.

It is interesting to note that configurations and cellular patterns may be drastically affected by some relatively small changes in the logical rules of certain genes but are not affected by a great majority of alterations.

However, given that most patients in the presented studies were assayed prior to systemic treatment, it is possible that the majority of alterations mediating acquired resistance to targeted therapies remain to be discovered.

While some potential driver genes could be rapidly identified from this data due to their location on focal alterations, the majority of recurrent alterations are large and encompass numerous genes.

The majority of observed alterations are affecting DNA methylation, a modification of cytosines introduced by DNA methyl-transferases (DNMTs).

Conversely, our data suggest that alterations to anatomy and cell biology were predicted to precede the majority of biochemical alterations, and that other enzymes of the C4 pathway are recruited prior to PEPC and RuBisCO.

Interestingly, while the female rats on the 20% CR diet showed a similar number of significantly altered pathways (48) the direction of the majority of pathway alterations was opposite to the pathways of the males.

Our data demonstrate that progressive leukoplakia lesions already possess many of the genetic alterations present in invasive cancers; this is consistent with the hypothesis that the majority of genetic alterations occur at an early phase during head and neck cancer progression (26).

39, 40 Accumulating data including chromosomal-alteration studies support the parallel disease theory 41, 42 and a great majority of molecular alterations detected in breast carcinoma can be detected already in DCIS.