A single oral administration of dh404 significantly enhanced myocardial expression of Nrf2 with the majority localized in cardiac myocytes (Figure 8A).
A number of recent studies have identified the presence of primary microRNA (miRNA) sequences throughout the HSV-1 and HSV-2 genomes, with the vast majority localized to the LAT locus (Cui et al., 2006; Tang et al., 2008, 2009; Umbach et al., 2008, 2009, 2010; Jurak et al., 2010).
While the repertoire and activities of SPI2 effectors remain largely unknown, the majority localize to the cytoplasmic face of the SCV and often along Sifs (Henry et al., 2006; Knodler and Steele-Mortimer, 2005; Salcedo and Holden, 2003; Kuhle and Hensel, 2002).
However, the majority are localized to transcriptionally silent loci dominated by conserved hypothetical ORFs.
Although it cannot be ruled out that a small proportion of these small EM48+ aggregates lacking a nuclear background were actually present in the nucleus, we believe that the majority were localized in the somatodendritic compartment.
Although RNA foci can be found in the cytoplasm, the vast majority are localized in the nucleus [ 17▪▪, 19 ▪].
Five such exons were confirmed experimentally, with the majority being localized in the juxtamembrane and first phosphatase domain in each of the four genes.
Only a small portion of CD74 is presented at the cell surface at any given time point, whereas the majority is localized in the endolysosomal compartment.
A majority of bacteria localized to cells expressing the enterocyte marker, with no significant difference in localization between wildtype and the SPI-1 mutant, suggesting that the SPI-1 encoded T3SS does not play a role in host cell type targeting in the intestinal epithelium during infection.
A great majority of proteins localized on the cell surface and in the ECM are transported outside through the classical ER-Golgi pathway for which the key mechanisms of molecular recognition and trafficking have been established [1], [2].
Remarkably, we found that all MMR proteins tested (MSH2, MSH6, and MLH1) were highly expressed in the majority of cells localized within the tonsillar GC compartment (Figure 1A) and the pattern of expression was similar to that of AID, a known GC B cell specific protein.
