In addition, the presence of Noxa was greatly decreased in the Mcl-1-immunodepleted supernatants of GSIXII-treated cell lysates compared with the corresponding not-depleted ones, indicating that GSIXII-induced Noxa was in the majority complexed to Mcl-1 (data not shown).
While the complexes in the benchmark 2.0 are transient complexes, the large majority of complexes in the PDB are obligate: no unbound form is available for them because their chains are never separated in vivo.
As for many other complexes, including a majority of complexes with amino acids and peptides, the irreversible part of the reaction is quite rapid (e.g. t1/2 <5 min for glygly), which excludes the use of the most commonly applied method based only on potentiometric titration [39 41].
The majority of complex disease variants were annotated by the bottom fifteen consequences categories, suggesting milder functional effect of complex disease variants compared to other three types of disease variants.
The group is widely reviled by the Buddhist majority for complex historical reasons, including resentment of British colonial policies that brought many people from India to the country.
Which is how Mr. Boehner felt about a Democratic majority using complex "reconciliation" procedures to push through Mr. Obama's health care plan last year.
A majority of complex scientific/engineering applications, however, fall in the category of precedence-constrained task graphs.
The key aspect of this system is that the majority of complex calculations required to facilitate the decision are carried out prior to the actual decision point.
The majority of complex molecules, such as medicines, fragrances, and flavorings that consumers use daily were invented by plants, fungi, and marine invertebrates.
According to many studies, a majority of complex, large-scale technological systems' accidents have been caused by breakdowns of the weakest links in this chain, most often the human or organizational subsystems (for further information see IAEA 1988; Meshkati 1990 , 1991 1992; NAE/NRC 2011; NAS/NRC 2014; Tabibzadeh 2014; Tabibzadeh and Meshkati 2014a, b, 2015; Meshkati and Khashe 2015).
