The great majority of association studies in asthma (and other diseases) which have considered the ADRB2 as a candidate gene for risk, severity or other clinical phenotype, or as a pharmacogenomic locus, have utilized one or both of the nonsynonymous coding polymorphisms.
So far, the majority of association studies involving plasma miRNAs were disease-specific case-control analyses.
For both CMIP and ATP2C2, the majority of association came from the five-syllable nonwords (p = 0.016 and p = 6 × 10−4, respectively) (Table S2).
It is obvious that nowadays, the majority of association studies use preferentially SNPs as genetic markers, since their frequency in the genome is much higher and they are located at many more sites of interest than microsatellites.
A recurring feature of the GWAS data derived for common polygenic traits is that the majority of association signals do not alter gene-coding sequences but rather are located within non-coding or intergenic regions.
It has to be noted that a vast majority of association studies performed in Caucasians were done in North European populations known to have a higher incidence of IBD compared to regions of the Southern Europe suggesting possible genetic differences in these populations.
In this respect, it is worth noting that the majority of association studies performed so far on common variants in nAChR gene cluster employed Western Europeans and Americans of European ancestry, while scarce data has been received so far from populations of Central Europe [ 40].
The majority of associations were for ER-negative breast cancer, with seven differential associations between AA and EA women for CYP24A1 (p for interaction < 0.10).
Associations with traits where few gene variants with strong effects are reported, e.g. rs6107516 in the prion protein PRNP associated with Creutzfeldt-Jakob disease (OR = 38.5) or rs2071348 in the hemoglobin gene cluster at 11p15.4 associated with beta-thalassemia (OR = 4.33), are exceptions from the majority of associations displaying small ORs [ 33, 34].
South West Norfolk is in no way representative of the majority of associations.
It is certainly true that in the past, the majority of associations selected predominantly white men with 2.4 children and a labrador via a sophisticated interview technique fondly known to candidates as "death by canapé".
