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A major virulence feature of the tuberculosis (TB) bacillus relies on the mechanisms it has evolved to parasitize host phagocytes [5], [6].
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Indeed, biofilm formation is a major virulence attribute of microorganisms and account for a majority of human infections.
Another key feature of the Cryptococcus HOG pathway is its involvement in production of two major virulence factors, capsule and melanin, and sexual differentiation [5], [6], [8].
Indeed the major virulence genes considered species-specific of S. pyogenes, are located on a non-phagic 47-kb SSR that carries features of a stabilized pathogenicity island [ 7- 9].
The major virulence factor for STEC infection is Shiga toxin.
PspA represents a major virulence factor and a promising vaccine candidate.
The nsp3 8 region was identified as containing major virulence factors, although mechanistic information is scarce.
The major virulence factors of this pathogen are the multi-domain toxins TcdA and TcdB.
In Vibrio cholerae, the T2SS secretes several unrelated proteins including the major virulence factor cholera toxin.
AmpR also regulates cyclic di-GMP phosphodiesterases (PA4367, PA4969, PA4781) possibly affecting major virulence systems.
Forty years ago, investigators reported that inhibition of phagosome maturation was the major virulence mechanism of M.tb.
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