This data suggests that the V3 loop, which is considered to be the major viral determinant for coreceptor specificity, is fundamental to induce DCs translocation across the epithelium.
The V3 loop of the env gene in HIV-C type is considered as a major viral determinant for coreceptor specificity.
Despite differences in viral replication kinetics for VSV and SeV in the seven cell lines, the observed pattern of RBV resistance was very similar for both viruses, suggesting that cellular rather than viral determinants play a major role in this resistance.
Determining both the viral determinants and cellular proteins involved may lead to novel therapeutic approaches.
A wide array of host and viral determinants influence which epitopes result in immune responses.
The viral determinants responsible for the increased virulence of these emerging WNV strains are poorly understood.
Coronavirus S protein is the major determinant for viral entry and host specificity.
The conditional depletion of HNF4α in the liver results in the loss of HBV transcription and replication indicating that this nuclear receptor is a major determinant of viral biosynthesis in vivo.
Another major determinant involves viral polymerase complex, more specifically, the PB2 subunit which has long been implicated in playing a crucial role in determining host tropism.
Using a genome-wide association study in C. elegans wild populations and quantitative trait locus mapping, we identify a 159 base-pair deletion in the conserved drh-1 gene (encoding a RIG-I-like helicase) as a major determinant of viral sensitivity.
