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Because of these major upfront investments, for downstream operations to be economically viable, they often require economies of scale, or a high enough volume of minerals extracted, to justify the fixed costs of developing the necessary infrastructure.
Just as importantly, the Imp could enable hardware from multiple manufacturers to work together, rather than having to rely on a single vendor for a home automation system that requires a major upfront investment and, frankly, probably won't be updated or age well with time.
It would also require major upfront tax increases to fund this expansion in exchange for the promise of a reduction in overall costs.
These results were entirely compatible with the other major upfront adjuvant aromatase inhibitor trial, the 'Arimidex', Tamoxifen, Alone or in Combination (ATAC) trial.
During 2001, MVP received proposals from 2 multinational vaccine manufacturers that required major upfront investments to develop and manufacture a vaccine with a price of about US$2.00 per dose, with the per-dose cost increasing significantly if <25 million doses were purchased annually.
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Kim, in turn, got at least one major benefit upfront.
While many TV stars hit the Big Apple this week for the major networks' upfront presentations, other stars jetted off to France to kick off the annual Cannes International Film Festival -- including Sacha Baron Cohen, who pulled quite a publicity stunt with Elisabetta Canalis.
The report more or less acknowledges that the pain would have been less with some major debt forgiveness upfront, but dismisses the notion of a more gradual adjustment on the grounds that the financing wouldn't have been available.
"We've closed the first major deal of the upfront," said Rob Tuck, executive vice president for national sales at CW, with "the C.E.O. of Bass Industries".
Now the debt-ceiling deal promises to reduce federal spending by $1 billion upfront, with major reductions promised in the near future.
Many fear past-due tax bills will eat up all the equity or require major chunks of cash upfront, but that's not always the case.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com