A major and unsettled issue in the worldwide emergence of CA-MRSA is the source of such isolates in the community.
Still, Mr. Sandalow and representatives of American biotechnology and agriculture companies stopped far short of declaring victory because major issues remain unsettled.
Until they do, a major issue will remain unsettled and admissions offices at universities around the country will remain confused about their legal obligations.
Lobbying, bargaining, negotiating and cajoling, she was a major player during a particularly unsettled period of European history.
Or to put it another way, Deutsche is saying that markets are unsettled because both major parties have been or would be held hostage by populist nationalist parties - UKIP for the Tories, and the SNP for Labour.
These elements refer to major policy change that occurs at politically unsettled times or crises, signals ideational and radical change (Hogan and Doyle 2009) and has lasting impact beyond one change of government (Donnelly and Hogan 2012).
Sowell said a major focus in preseason has been on creating transition and unsettled offense so he was pleased that a "fair amount" of the 13 goals Navy scored against Ohio State on Wednesday came in such situations.
Obviously unsettled as well were relations with Serbia, still a major trading partner.
Western oil companies such as ConocoPhillips steered clear of the sale; Exxon Mobil recently said the unsettled situation in Russia would keep it from making major investments there.
But, as John Llewellyn and Russell Jones of Llewellyn Consulting remind us in their latest weekly comment: "In or out of the EU, the country is confronted by major economic challenges and the political environment is likely to remain fraught and unsettled".
