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Therefore, a major unresolved question for the majority of SUMO substrates is exactly how SUMOylation is initiated and regulated.
Fouling is a major unresolved problem in heat transfer.
However, there are still several major unresolved issues that need to be addressed.
A major unresolved question is the basis for this selective neuronal vulnerability.
However, the effective labelling and tracking of MSCs in vivo remain major unresolved issues.
Sepsis continues to be a major unresolved medical challenge of the present.
"A major unresolved issue is how to fund this effort," Mr. Billington said.
But it needed "strong leadership" because there were "major unresolved green belt issues".
A major unresolved issue is how quickly newly arrested Afghans should be turned over.
Sarah's major unresolved loss is that of her childhood best friend, Jennifer Jones.
There are major unresolved differences including over the future of Mr Assad.
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