Sentence examples for major underlying mechanisms from inspiring English sources
A growing body of evidence has demonstrated that CFTR is involved, directly or indirectly, in the transport of HCO3−, defects of which could be one of the major underlying mechanisms for CF-related clinical presentations [24].
P-gp is encoded by the MDR1 gene and its overexpression is one of the major underlying mechanisms of MDR.
This may be one of the major underlying mechanisms in obesity-related diseases [ 7], explaining the clustering of WC together with hyperleptinemia and hypoadiponectin.
Although the physiological mechanisms underlying this 'obesity paradox' are not well understood, poor nutritional status, protein energy wasting and inflammation, which often coexist with lower BMI in advanced CKD, are thought to be major underlying mechanisms responsible for increased mortality in this population [ 20].
TCM preparation, Chinese materia medica and their active compounds show potential to ameliorate I/R-induced cerebral microcirculatory disturbances, brain injury and neuron damage with anti-inflammation, anti-oxidation, anti-apoptosis, anti-excitoxicity and pro-neurogenesis as the major underlying mechanisms.
Oxidative stress has been suggested as the major, underlying mechanism behind many of the toxic reactions induced by air pollutants [ 6].
This is a major potential underlying mechanism that links atherosclerosis and cardiovascular disease with air pollution exposure.
It has been hypothesized that dysregulation of brain-expressed genes is the major predisposing underlying mechanism for autism.
Although an exact evaluation of the pathophysiological pathways is beyond the scope of the present study, we assume three major possible explanations for underlying mechanisms that may lead to an association between the UPSM score and newly diagnosed T2DM risk in our study population.
Oxidative insensitivity and methylation status of the F7 RR/RR genotype seem to play important roles for resistance to SCMV and MDMV, pointing towards post-transcriptional gene silencing as major underlying defence mechanism.
Understanding this process and the underlying mechanisms remains a major research goal.
