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'major trouble' is correct and usable in written English.
You can use it to describe a big problem, difficulty, or challenge someone is facing. Example sentence: His reckless behavior has caused him major trouble this time.
Exact(60)
If you did, it would be major trouble.
Strathclyde police said there had been no major trouble overnight.
"Essentially, what you are saying is that when a sick individual comes into that school, they can expect major trouble, right, major trouble.
The BP move comes alongside major trouble for other Western solar companies.
Although tests of TGN1412 in monkeys showed no major trouble, all six human subjects nearly died.
We knew that this could mean major trouble for the Floating Forest.
Abby's a brilliant heroine; self-possessed, moral and permanently on the verge of major trouble.
There were, however, several major trouble spots in the markets during the half that singed some fingers on Wall Street.
It doesn't mean the rule isn't in major trouble — but it's unlikely to go down without a fight, either.
They are now confident that most major trouble spots between Gibraltar, a British colony, and Spain will be resolved.
In between points, however, she has been wearing her game face, the introspective look that traditionally means major trouble for the opposition.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com