Sentence examples for major transforming from inspiring English sources

From our findings we conclude that the mutation E17K/ AKT1 is unlikely to cause major transforming activity in B-cell-origin CLL, ALL and PLL.

The major transforming activity of BPV-1 E5 is due to its ability to specifically bind and activate PDGF βR in a ligand independent manner, and, importantly, it does not activate other related receptors [ 15– 15].

LMP1 is the major transforming protein of EBV, behaving as a classical oncogene in rodent fibroblast transformation assays and being essential for EBV-induced B-cell transformation in vitro [32].

SV40 studies have shown, LT antigen to be the major transforming protein involved in neoplasic processes, deregulating p53 and retinoblastoma family members, whereas ST antigen cooperates with SV40 LT antigen to induce cell transformation [28], [29].

In HeLa cells we detected transcription products for the two major transforming genes of HPV-18, E6 and E7 (panel D).

Therefore, most studies on HPV16 variants have focused on E6, the major transforming protein that inhibit apoptosis and promote proliferation and their association to cancer aggressiveness [ 9- 11].

The compositional trend of the Oligocene-Miocene (Takinoue) volcanic rocks is in accord with that observed in Grenada, which is located in the vicinity of a major transform plate boundary (Niida 1992).

We compare fault-related deformation of three segments of the major transform plate boundary between Africa and the Arabian plate, the Dead Sea Transform (DST), namely the Arava/Araba fault (Jordan/Israel), the Serghaya fault and the Ghab fault (both Syria).

The Marmara Sea, accommodating the fault segments of a major transform fault, is well known as a seismic gap along the North Anatolian Fault (NAF), running through the northern part of Turkey and connecting the East Anatolian convergent area with the Hellenic subduction zone (e.g., Pınar 1943; Toksöz et al. 1979; Pondard et al. 2007; Şengör et al. 2014).

This conclusion has implication also on the mechanism and the origin of the Pantelleria Linosa Malta Rift that is here interpreted as a transtensive feature developed along a major transform fault, rather than the result of passive rifting induced by the Nubia Eurasia collision, as it is currently interpreted.

During the steeper dip subduction phase, it is likely that the NYT experienced a slightly greater degree of extension than the SYT, raising the possibility of a slab segmented by a major transform fault resulting in slightly steeper subduction beneath the NYT.