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Banoxantrone (AQ4N) is another agent that is showing promise in early phase I/II clinical trials; the drug is well tolerated, is known to locate in the tumour and can be given in high doses without major toxicities.
The major toxicities of ixabepilone in this trial were neutropenia, peripheral neuropathy, diarrhea, dyspnea, and fatigue.
Major toxicities included two cases of grade 3 diarrhea or colitis and one case of symptomatic panhypopituitarism (grade 2 hypophysitis).
The major toxicities were neutropenia and thrombocytopenia.
Major toxicities were neutropenia and diarrhoea.
The major toxicities were neutropaenia and thrombocytopaenia.
Major toxicities encountered were infective and cardiovascular.
Major toxicities are listed in Table 2.
The major toxicities were leucopenia and thrombocytopenia.
One of the major toxicities related to docetaxel is myelosuppression.
Major toxicities were manageable grade 3/4 thrombocytopenia and neutropenia.
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