Sentence examples for major toxic side from inspiring English sources

The major toxic side effects are agranulocytosis, musculoskeletal and joint pains, gastric intolerance, and zinc deficiency.

No major toxic or unusual side effects were observed and efficacy was similar to that observed in published trials.

Our present experience suggests that in the treatment of head and neck cancer, superselective intra-arterial infusion with high doses of carboplatin delivered directly to the tumour bed is a safe and well-tolerated technique with no major systemic or local toxic side effects.

Currently, the selection criteria for using or withholding chemotherapy are coarsely defined; however, this selection is of major importance in order to avoid unnecessary toxic side effects associated with therapy (Goldhirsch et al, 2009).

Therefore, the effects of indiscriminate disruption of major cytoskeletal networks may contribute to metastasis or toxic side effects.

Lack of selectivity and short blood circulation time which cause various toxic side effects are also issues of major concern [ 42].

However, toxic side effects of Pt-based drugs are major drawbacks in cancer therapy [6, 7].

In conclusion, it is a major challenge to identify patients with a considerable risk of unnecessary toxic side effects and limited benefit from treatment.

A major drawback of current treatments against KRAS-driven lung cancer is the toxic side effects of the drugs due to the lack of selectivity between cancer and normal cells.

However, problems associated with toxic side effects and poor quality of life in cancer patients remain a major issue [ 77].

The F.D.A. said a major reason it rejected ImClone's application was that the company had not shown that irinotecan, which has toxic side effects, was really needed.