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Thus, by combining epidemiological data concerning snake bites with genomic, tanscriptomic, proteomic and immunochemical analyses of the major toxic components of venoms, we were able to provide a clear description of the potential neurotoxicity of Vipera aspis bites in France.
Phorbol esters are thought to be the major toxic components of seeds.
Despite this promising application, jatropha seeds contain two major toxic components, namely phorbol esters and curcins.
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Previously antibodies generated against a single major toxic component of venom have proven to be an effective strategy for antivenin production.
Nicotine is the major toxic component of cigarette smoke and may interact with the nicotine acetylcholine receptor in many cells.
The chemical nature of piscine venoms is poorly known, though the loss of toxicity seen when these venoms are subjected to common denaturing agents suggests that proteins constitute the major toxic component of these secretions [ 16].
Nevertheless, the data support animal studies suggesting that male and female mouse fetuses exposed to polycyclic aromatic hydrocarbons, the major toxic component of cigarette smoke, have reduced fertility, although the precise mechanisms of this association are unknown.
The major toxic component of the pulse is ODAP, a neurotoxin amino acid [ 3, 4], which can potentially act as an agonist at certain glutamate receptors and [ 7, 8] inhibit specifically tyrosine aminotransferase [ 9] and chelates metals like zinc [ 10] that is also present in the longevity promoting Ginseng root [ 11].
In conclusion, we have shown that air pollution particles have two major classes of toxic components.
This technique involves the use of two major non-toxic components, a photosensitizer (PS) and a visible or near-infrared (NIR) light source, combined to induce cellular damage in an oxygen-dependent or -independent manner.
To see whether melittin, the major (over 50%) toxic component of the BV, is responsible for the above abnormal pain behavioral changes, the present study was designed to investigate the effects of s.c. melittin on either nociceptive behaviors in conscious rats or spinal dorsal horn neuronal responses in anesthetized rats.
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