Since the major tissue sources of serum PHM and PAL remain unknown, it is difficult to interpret this unexpected result.
Finally, as presented here, the major tissue or cell source of paracrine factors modulated by the bone-tumor interactions can only be presumed primarily due to the complexity of the bone tissue.
Aromatase activity is essential for catalyzing the conversion to estrogen of steroid precursors in peripheral tissues, the major source of estrogen production in postmenopausal women.
Although plasma NEFAs did not differ between LF- and HF-fed mice, these were measured after a 24 h fast, when NEFAs release from adipose tissue constitutes the major energy source and is maximal.
This condition results in a negative energy balance, to which dairy cows adjust by lipid mobilization from the adipose tissue representing a major fuel source during the transition period (Sordillo and Raphael 2013).
Transgenic mice with Angptl4 overexpression directed to heart muscle (lipoprotein-derived fatty acids are the major energy source in this tissue) show reduced cardiac LPL activity, decreased triglyceride utilization and impaired cardiac function resulting in cardiomyopathy [ 41].
Mononuclear cells are major sources of tissue pro-inflammatory cytokines [ 19].
ELN, a self-assembling extracellular matrix protein, is the major source of tissue elasticity [ 57].
Depending on the cell and tissue, the major ROS sources are the dedicated producers: NADPH oxidase, (NOX) complexes (7 distinct isoforms) in cell membranes, mitochondria, peroxisomes, and the endoplasmic reticulum [ 92].
Fatty acids that are stored in adipose tissue as triglycerides are a major energy source in higher animals, as is glucose, a simple six-carbon carbohydrate.
