Sentence examples for major target to from inspiring English sources

This results in constitutive activation of the PI3K/Akt pathway which then represents a major target to prevent dysfunctions in cell growth, survival and motility.

Thus, EMT is a major target to break the deleterious cycle of cancer.

All these published results lead to the hypothesis that the major target to avoid relapse and metastasis in cancer are the hybrid phenotype (epithelial and mesenchymal) cells.

However, we and others previously showed that AGC kinases-mediated phosphorylation of Rictor at T1135 does not significantly affect mTORC2 complex integrity and its kinase activity (Dibble et al., 2009; Gao et al., 2010), which urged us to further examine whether the other mTORC2 essential component, Sin1, is a major target to mediate mTORC1/S6K's negative regulation of mTORC2.

These results indicate that GFAP is a major target to modify astroglial reactivity and consequently neuron-glia interactions for therapeutic purposes.

New antithrombotic treatment is a major target to improve prevention of vascular events in patients with PAD.

These CTLA-4+/CD39+ Treg are major targets to inhibit their suppressive function, thus promoting anti-tumour immunity in the TME.

And his major target is to lead Guinea to the 2015 Africa Cup of Nations in Morocco.

A major target is to avoid expensive starting materials and to broaden the range of possible products.

This paper includes a description of the progression of mousepox infection in mice, from the time/site of virus entry, to the time/sites of infection of major target organs, to the time/sites essential for virus transmission.

"The bill does other things, but certainly, a major target is to deal with peoples' housing issues and try to stem the tide".