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Distributional pattern of ZnO-NPs reveals that the intestine is the major target tissues for NP toxicity.
The distribution pattern of ZnO-NPs indicates that the intestine is the major target tissues for NP toxicity.
We systematically analyzed by Western blotting the expression levels of proteins in the insulin signalling pathway in skeletal muscle, one of the major target tissues of insulin action and the major site of postprandial glucose disposal.
In this sense, it is remarkable that bearded vultures primarily feed upon livestock bones, which are one of the major target tissues of fluoroquinolones in medicated animals [56], therefore, rendering this species especially sensitive to the consequences of an increase in the consumption of stabled intensively medicated livestock.
Originally, it was assumed that the beneficial effects of ligand activation were mediated by PPARγ in one of the major target tissues of glucose and lipid metabolism, such as muscle, fat or liver.
The 25-hydroxyvitamin D re-enters the circulation and is converted in the kidney by 25-hydroxyvitamin D-1 α-hydroxylate to 1,25-dihydroxyvitamin D, which regulates calcium metabolism through its interaction with its major target tissues, bone and intestine; 25-hydroxyvitamin D is also metabolised in colorectal mucosa for regulation of cellular growth.
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The distribution pattern of ZnO-NPs may indicate that intestine is a major target tissue for NP toxicity.
The OSE is a major target tissue for ovarian carcinoma formation.
The synovium is a major target tissue in chronic arthritis and is intensively studied at the cellular and molecular level.
Skeletal muscle is a major target tissue of insulin, and its insulin resistance leads to the development of type 2 diabetes (1– 3).
Skeletal muscle is a major target tissue for insulin-stimulated glucose disposal [ 1, 2], and insulin resistance in this tissue is considered a key factor in the development of Type 2 diabetes.
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