It may be hypothesised that reduced fearfulness has been a major target of selection during domestication.
These results indicate that Pin1 is essential for the Neu/Ras-induced transformation of mammary epithelial cells and that cyclin D1 is the major target of Pin1 during this transformation.
MAPK pathway is one of the most extensively studied pathways involved in tumorgenesis [ 48] and has proven to be a major target of Meq during tumor formation by chromatin immunoprecipitation sequencing [ 49] and RNA sequencing [ 50].
The disorganized F-actin in 2DG-treated SVEC4-10 cells is similar to death-associated protein kinase-induced cell death, indicating that the actin cytoskeleton is a major target for destruction during the process of apoptosis (Ivanovska et al., 2014; Leadsham et al., 2010).
Collectively, these results demonstrate that PPARγ is one of the major target genes of EZH2 during neuron differentiation of hMSCs and that its expression is suppressed at the MSC stage.
It appears that the major target of evolutionary force during evolution of eucaryotes are the regulatory circuits that link metabolism, which provides the cellular fabric plus fuel with that of the genome, which encapsulates the genetic program.
In fibroblasts, one of the major target cells of IGF1 during wound healing, we analyzed key intracellular molecules within the IGF1 signaling pathway using immunoprecipitation, western blotting and ELISA-based techniques.
With considerable gene expressional and phenotypic divergence between wild and cultivated rice, the panicle might have been an major target for artificial selection during domestication, a hypothesis consistent with the finding that many yield-related traits are associated with panicles [ 20].
Considering RbcL as a major target, its enclosure in carboxysomes during the later cyanobacterial radiation could have made some of the protective mechanisms against oxidative stress dispensable.
This structural protein represents the major target of cellular immune response during HCMV infection [20], [21], and also in vitro HCMV-infected cells are recognized by 70 90% of cytotoxic T lymphocytes (CTLs) [22].
