"Granting agencies are often loathe to support investigators who are making a major switch of this sort," says Coppel, one of 11 Australians, the most from any one country.
"Granting agencies are often loath to support investigators who are making a major switch of this sort," says Coppel, one of 11 Australians, the most from any one country (see pie chart).
He adds that it will help in finding the genes that are the major switches for turning on particular kinds of behavior.
We have shown that one of the major switches related with melanoma progression is the loss of expression of the transcription factor AP-2α [15].
Currently we favor the view that CD28 and CTLA-4 are the major switches that regulate the early outcome of TCR engagement during naive T cell activation but can also shape the composition and function of the primed T cell pool.
A major switch in the structure of the country's economy came with the Mulungushi Reforms of April 1968, in which the government declared its intention to acquire an equity holding (usually 51 percent or more) in a number of key foreign-owned firms, to be controlled by the Industrial Development Corporation INDECOO).
Over recent weeks, consultants working on behalf of the watchdog have been auditing each of the major switching websites to establish whether they conform to its new code of conduct.
Although there are many diverse primary signals that initiate the cascade (e.g. X A ratio, M-factors, W/Y chromosomes; see [ 1]), dsx appears to be conserved as the major switch at the base of the cascade [ 8, 9].
Our data and models show that in a striking coincidence winter annual seeds are set when the mean temperature is approximately 14 15°C, the temperature at which a major switch from the production of dormant to non-dormant seeds occurs.
For example, identification of the recombination events underlying a major switch in substrate specificity during evolution of a bacterial non-ribosomal peptide synthase, allowed Crüsemann et al. [ 36 ] to create enzyme variants that accepted alternative substrates, based on the inferred recombination points.
