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The chromosomal region lq41-42 contains major susceptibility genes of SLE23,24.
eIF4E translation initiation factors have emerged as major susceptibility factors for RNA viruses.
In this review we highlight current research on models of major susceptibility loci and the information accrued from their analysis.
Our data suggest that neither variant rs75932628 nor rs2234253 be a major susceptibility factor of sporadic PD in Chinese Han population from Mainland China.
One locus, located in an intergenic region of chromosome 8q24, has been implicated in all GWAS and constitutes a major susceptibility locus.
The study of the genetic underpinnings of inflammatory bowel disease has made great progress since the identification of NOD2 as a major susceptibility gene.
Dr. Ottman's research group was the first to recognize the familial epilepsy syndrome "autosomal dominant partial epilepsy with auditory features" and to identify LGI1 as a major susceptibility gene for the disorder.
Linkage studies, designed to identify major susceptibility genes in a disease, have produced a number of candidate loci but few, except for regions on chromosome 5p15, 20p and 20q, have been replicated.
Thus, there is no current evidence that the genes causing FHM represent major susceptibility loci for the typical migraines.
This 24/7 internet-connected wallet, is a major susceptibility, which according to Proffitt, combined with the volume of funds they hold, makes these exchange wallets a prime target for hackers.
Cblb is a major susceptibility gene for type 1 diabetes in the Komeda diabetes-prone rat [60].
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