Sentence examples for major subtypes based from inspiring English sources

Earlier publications categorized neuroblastomas into three major subtypes based on cytogenetic profiles: Subtype 1: favorable neuroblastoma with near triploidy and a predominance of numerical gains and losses, mostly representing non-metastatic NB stages 1, 2 and 4S.

Multiple sclerosis (MScl) can be divided into two major subtypes based on clinical representation of disease symptoms in the patients [1].

Additionally, influenza A is further classified into major subtypes based on genetic and antigenic differences in the membrane glycoproteins hemagglutinin and neuraminidase [7].

More recently, DNA microarray studies have suggested a refined classification of breast cancer, distinguishing five major subtypes based on different patterns of gene expression, underlying DNA copy number alterations (CNAs), and associated clinical outcomes [2] [5].

Stroke was classified into its major subtypes based on available clinical and diagnostic test information, including brain scans with excellent inter-rater agreement.

Non-fatal stroke was confirmed if the participant had a new focal-neurological deficit of sudden or rapid onset that persisted for >24 hours and attributed to a cerebrovascular event, and was classified into its major subtypes based on available clinical and diagnostic information with excellent interobserver agreement.

Extensive clinical data were collected for lung cancer cases, including morphology coded according to the International Classification of Diseases for Oncology, Third Edition (31) and categorized into major histologic subtypes based on World Health Organization/International Association for the Study of Lung Cancer classification (32).

We also explored possible effect modification by the major breast cancer subtypes based on hormone receptor status: ER+/PR+ and ER-/PR- (Tables  6 and 7).

HCV has six major genotypes and numerous subtypes based on its positive-strand RNA genome, and a seventh major genotype was recently discovered [25].

The clustering pattern in the tree is consistent with the functional diversification and differentiation of the histone subtypes based on a birth-and-death model of evolution [ 28], ruling out a major effect of a concerted evolution mechanism.

We identify four subtypes based on 15 diagnostic categories.