Sentence examples for major substitution from inspiring English sources

Some companies have said the cost of a major substitution can run to millions of dollars for a single product line, he adds.

However, A to G substitutions did not represent the major substitution pattern (Fig. 4).

We illustrate this approach by identifying major substitution patterns of phenolic aromatic moieties of a peat soil fulvic acid, an operational fraction of humic substances.

The positions of major substitution sites corresponded with the following known RNA base modifications in tRNAs: N1-methyladenosine (mA), N2-methylguanosine (mG), and N2-N2-methylguanosine (m2G).

If a given position had more than one type of substitution meeting the above criteria, only the major substitution was counted.

This result suggests that major substitution events that occurred during the evolution of the cultivated monocot hbs were A→G and T→C transitions, and thus indicates that in these genes the GC content is high.

In particular, two major substitutions in the residues that define the nucleoside triphosphate binding site can be identified.

However, if we focus our attention to the entire protein sequences, we can observe that compared to the BH10-derived p17, the Ugandan variant S75X displays major substitutions that are not limited to the region that is truncated in p17Δ36, but scattered throughout the whole protein sequence (Figure 9).

During the epidemic turnover of dominant variants from clade 2B-1 to 2B-2 viruses within the two influenza seasons of 2007 2008 and 2008 2009 in Taiwan, several major substitutions were detected without genomic reassortment, including A206T in HA, H275Y and D354G in NA, N642S in PB1, L30R and H41P in PB1-F2 and V411I and P453S in PB2 (Table 3).

We also analyzed the four Amphimedon (poriferan) sequences and found that none of the key residues in the calcium binding loops have major substitutions (Additional file 4).

The frequencies of resistance-associated mutations [ 9] were calculated both for all participants (intention-to-treat) and for participants who had made no major substitutions (defined in the Results section) to their initial regimen (on-treatment).