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Lepidopteran blood cells are generally classified into five major subsets based on morphology and functions [3], [4], [10], [11] (Supplementary data Fig. S1).
RA can be divided into two major subsets based on the presence of ACPA.
Human NK cells can be divided into two major subsets based on the expression of CD56 [ 8].
Rheumatoid arthritis (RA) can be divided into two major subsets based on the presence or absence of antibodies to citrullinated peptide antigens (ACPA).
Three major subsets based on the expression of CD14 (the lipopolysaccharides (LPS) co-receptor) and CD16 (the FcγRIII low affinity immunoglobulin G (IgG) receptor) have been defined in circulating monocytes [ 6, 8- 10].
In humans, monocytes (all of which express CD115+) are divided into the two major subsets based on their CD14 and CD16 expression, as well as on their expression of markers called CCR2 and CX3/CR1: The predominant subset, representing 90percentt of circulating monocytes, is the classical subset characterized by the marker combination CD14hiCD16− and CCR2+/CX3CR1lo.
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HCM can be classified into at least five major anatomic subsets based on the septal contour, as well as the location and extent of hypertrophy: reverse curvature, sigmoidal, symmetric, apical and neutral contour.
The results from subgroup analysis by ACPA seropositivity revealed the association of BMI or obesity with RA risk in ACPA-positive RA rather than ACPA-negative RA, suggesting that BMI plays a different role in these two major RA subsets based on the presence of ACPA.
The estimation set is divided into k subsets (based upon subjects), of which k - 1 subsets form the training set and the remaining subset forms the validation set.
After performing PCA on the residuals comparisons of the subsets based on positively loaded versus negatively loaded subsets were performed.
However, due to the unavailability of the cause-specific emergency department visits, we failed to explore the exposure-response association based on major subsets of outcomes, such as cardiovascular or respiratory diseases.
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