The major studies used the GHRH-arginine test as the primary test to evaluate the GH-IGF-1 axis, adopting a peak GH of 9.0 mcg/L as a cut-off value, whereas recent clinical practice guidelines recommend a limit value of 4.1 mcg/L [ 102].
In a major study using EISCAT, Ogawa et al. (2014) have shown a cooling trend of 10 15 K/decade near the F region peak (220 380 km altitude), whereas above 400 km, the trend appears absent or may even indicate warming.
Another major difference with studies using IAMs is that ours rely on state-of-the-art Earth system models.
The major difficulty with studies using large numbers of tests, especially using the new high density SNP panels, is setting an appropriate correction for multiple testing.
A major concern in studies using cultured primary neurons is that differences in culture conditions, handling procedures and stimulation paradigms will cover the real dynamics of nucleocytoplasmic shuttling in response to synaptic activity.
Indeed, the risk of over- or under-reporting from students or the tendency to project favourable images of oneself (social desirability) are major problems in studies using self-reports.
Major phytotoxicity studies use a seed germination technique.
This paper explores the current status of healing and intention research, citing a number of major studies and using the "Study of the Therapeutic Effects of Intercessory Prayer (STEP) in Cardiac Bypass Surgery Patients: A Multicenter Randomized Trial of Uncertainty and Certainty of Receiving Intercessory Prayer" as a case study of this line of research.
The major limitation of these studies using subjectively based measures as a key risk factor is the inconsistent terms used to describe ground hardness.
The retrieved biomarkers and the major findings from key studies using these biomarkers are listed in Tables 1, 2, 3, 4, 5, 6, 7, 8 and 9. Of the 178 biomarkers, 18 had been evaluated in experimental studies only, 58 in both experimental and clinical studies, and 101 in clinical studies only.
