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Overall, there were no major structural perturbations due to the mutation.
Therefore, we concluded that we achieved deflavination without major structural perturbations and used these deflavinated species for further analyses.
Circular dicroism spectroscopy was used to show there were no major structural perturbations induced by the mutations (Supporting Information).
Several variants are conservative and would not lead to major structural perturbations, in particular mutations in the CAMD and the rod domain.
Consistent with such a mechanism, the D620N mutation does not compromise the steady-state levels of VPS35 and its normal localization to early and late endosomes and lysosomes within cortical neurons, suggesting the absence of major structural perturbations to VPS35.
Similar(55)
The structure of RTP.C110S, solved to 2.5 Å resolution using crystallographic methods, showed no major structural perturbation due to the mutation.
As an isostructural analogue of Cys, selenocysteine (SeC) can replace Cys without major structural perturbation.
This model allows for the identification of the structural perturbations of point mutations on the overall tertiary cofactor structure.
"We are concerned to find there are major structural difficulties.
Could major structural changes be on the cards?
Major structural reorganisation and endless tinkering initiatives will not help".
More suggestions(15)
major structural alterations
major structural changes
major structural failures
large structural perturbations
severe structural perturbations
major climatic perturbations
major structural issues
major structural deficiencies
major structural proteins
major genetic perturbations
major metabolic perturbations
major structural difficulties
major genomic perturbations
major structural features
major structural reforms
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