Sentence examples for major structural alterations from inspiring English sources

We show that, rather than undergoing major structural alterations or 'folding' upon binding, the majority of TCR CDR loops shift by relatively small amounts.

Consequently, removal of all heptad-repeats lead to major structural alterations and corresponding loss of enzymatic activity [59], [60].

The morphology of the tissue sections at different time points showed that decidual tissue does not display major structural alterations before day 18 (Fig. S1).

While it is not possible to deduce glycan structures simply from gene expression of glycogenes, expression alterations in glycogenes provide insights on major structural alterations as well as leads on target points for therapeutic intervention.

From a total of 69 MTBC isolates analysed 36 (52%) were found to contain major structural alterations.

We showed that major structural alterations of the NMJs were present in all ALS patients and that NMJ loss of innervation correlated with Nogo-A muscle expression.

In contrast, this mutation induces major functional and structural alterations of the whole trimeric langerin extracellular domain (Lg-ECD).

Major liver qualitative structural alterations are depicted in Figure 3.

Major kidney qualitative structural alterations are depicted in Figure 4. Marked interstitial haemorrhage (Fig. 4A and 4B) and the collagen deposition in the interstitial space and surrounding large vessels, was observed.

Major lung qualitative structural alterations are depicted in Figure 2. Lungs showed a marked alveolar collapse and enlargement of alveolar walls (Fig. 2A), apparently explained by the pronounced vascular congestion, interstitial edema and by collagen deposition, evidenced by van Gieson staining in 4 and 6 days-survival victims.

Only a few renal corpuscles had major ultrastructural and structural alterations and no change in serum creatinine or creatinine clearance was observed.