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The stressor initiated a major stress response as indicated by increased normalised expression of two stress-responsive genes, Transcription Factor JUNB and cytochrome C (pink salmon only).
Childhood maltreatment can trigger enduring changes in major stress response systems, particularly in the context of major depressive disorder (MDD).
Salivary cortisol (sCort) and salivary alpha-amylase (sAA) constitute proxy measures of the two major stress response systems, i.e. the hypothalamic-pituitary-adrenal axis and the autonomic nervous system, respectively.
Finally, it has been recently demonstrated that in aged cells one of the key aging-related processes previously considered irreversible, attenuation of the expression of a major stress response protein, Hsp70, can be reversed.
JNK signaling is one of the major stress response pathways, which often triggers apoptosis.
While we cannot rule out that centrosome defects lead to significant post-transcriptional changes without affecting the transcription of many genes, our findings strongly suggest that centrosome defects do not induce a major stress response in these cells.
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Finally, restoration of cell viability did not appear to be the result of a decrease in growth rate or an induction of major stress responses.
One of the major stress responses to trauma is the activation of the HPA axis to increase cortisol production.
Many, or possibly most major stress responses in E. coli include at least one small regulatory RNA as part of the regulon [ 2].
Autophagy and apoptosis are two major stress-response pathways.
Furthermore, the major stress-response gene, Hsp22, a mitochondrial chaperone of the lens-crystallin superfamily, was upregulated (Morrow et al., 2000; Michaud et al., 2002).
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