Sentence examples for major splice variants from inspiring English sources

Heterologous expression of the three major splice variants of the rat PAC1 receptor, PAC1hop, null and hip, in neural NG108-15 conferredferred PACAP-mediated intracellular cAMP generation, while elevation of [Ca2+]i occurred only in PAC1hop-, and to a lesser extent in PAC1null-expressing cells.

There are three major splice variants called QKI-5, QKI-6 and QKI-7 that encode different protein isoforms.

As reported in that study, there are two major splice variants for the coding sequence of zebra finch FoxP2.

In most CEACAM1-expressing cell types, the molecule occurs in two major splice variants differing in their cytoplasmic domain, called CEACAM1-L and CEACAM1-S.

Furthermore, CEACAM1 occurs in four major splice variants with either three or four Ig domains and either a short (S) or a long (L) cytoplasmic domain consisting of 12 aa or 73 aa residues, respectively, giving the following variants: CEACAM1-3S, CEACAM1-3L, CEACAM1-4L[15] CEACAM1-4L[15], [17].

The major splice variants are VEGF121, VEGF165, VEGF189 and VEGF206.

When recombinantly expressing ADAR2R in HeLa and HEK293 cells, we did not detect any differences in general adenosine deaminase activity displayed by ADAR2R compared to the ADAR2a major splice variant (data not shown).

Primers for identification of the major splice variant are presented in Table 1.

In conclusion, the CD44+ lymphoma cell lines expressed mainly CD44s, which as major splice variant of normal lymphoid tissue is believed to exert tumor suppressor functions.

RT-PCR analyses of cDNA derived from zebrafish embryos at different developmental stages confirmed that this is the major splice variant (see Fig. S4A,B in the supplementary material).

The red staining on the blot indicates the presence of nascent amelogenins and shows several alternatively spliced amelogenin species, including the major splice variant, P173, confirming that the enamel sampled was indeed secretory-stage enamel.