Sentence examples for major signalling targets from inspiring English sources

To design therapeutic tools that not only interfere with TNF signalling but also effectively block TNF-mediated inflammatory responses, it is essential to identify the major signalling targets of TNF in inflammatory joint disease.

However, if we are to design therapeutic tools that can effectively block TNF-mediated inflammatory responses, then we must define the major signalling targets of TNF in inflammatory joint disease in vivo.

Plants actin cytoskeleton is a major signaling target and in response to numerous abiotic and biotic stimuli, it changes dramatically in various ways, ranging from filament bundling, to massive actin depolymerization, to assembly of new filament arrays [ 55– 55].

In addition, dgk‐1 is involved in serotonergic signaling, one of the major signaling pathways targeted by antidepressants such as Mianserin (Nurrish et al., 1999).

Accordingly, drugs that perturb IPMK signaling actions on major metabolic signaling targets, such as Akt, mTOR, and AMPK, may have therapeutic applications for metabolic syndromes (e.g., obesity, type 2 diabetes) and related eating disorders, such as bulimia and anorexia nervosa.

We targeted the three major signalling pathways downstream of Ras - MAPK, PI3-K and p38MAPK.

We next examined the effects of various inhibitors targeting major signaling pathways on Sema4A-induced IL-6 upregulation in RASFs.

Our findings not only reveal an epigenetic mechanism for BRAF V600E-promoted NIS silencing involving histone deacetylation at critical regulatory regions of the NIS promoter but also provide further support for our previously proposed combination therapy targeting major signaling pathways and histone deacetylase to restore thyroid gene expression for radioiodine treatment of thyroid cancer.

This study not only uncovers an epigenetic mechanism involving histone deacetylation at critical regulatory regions of the NIS promoter for BRAF V600E-promoted NIS silencing but also provides further evidence supporting our previous proposal to use a combination strategy targeting major signaling pathways and HDAC to restore thyroid gene expression and radioiodine avidity (Hou et al. 2010).

The screen allowed us to establish a direct link between Gcm and three major signaling pathways, the vast majority of whose members are targeted by Gcm.

One major challenge will be to find cellular redoxosome-associated targets that are specific enough to avoid disrupting major signaling pathways that are crucial to good health.