Sentence examples for major signalling effector from inspiring English sources

The absence of GIRK channels, a major signalling effector for GPCRs, in mouse DRG, raises concerns over the predictive validity of mice as a model organism for investigating peripheral GPCR-mediated analgesia.

The two major signaling cascades the Fas-mediated extrinsic and mitochondrial intrinsic pathways [ 34] eventually converge to form a final common effector pathway involving caspases 3, 6 and 7 [ 35].

Potential for plasticity of signalling pathways illustrated through expression patterns of signalling effectors.

Despite AKT signaling being a major downstream effector of PI3-K signaling, there is mounting evidence to suggest the importance of other signaling factors downstream of PI3-K that act independently of AKT to mediate important cell processes that are involved in malignant transformation.

In NRAS mutated melanoma cells, CRAF was demonstrated to be the major RAS effector for signaling through ERK [27], [28].

Taken in the context of previous studies with MyD88 (myeloid differentiation primary response gene 88) and TLR2 (Toll-like receptor 2) KO animals, the current report advances our understanding of MyD88-dependent cascades and implicates IL-1RI signalling as a major antimicrobial effector pathway during acute brain-abscess formation.

Furthermore, cardiomyocyte-specific deletion of signal transducer and activator of transcription 3 (Sthe3), the major downstream effector of IL-6 signaling, decreased reactive cardiomyocyte proliferation after apical resection.

Arm protein is both the major nuclear effector of Wg signaling and a major component of adherens junctions.

FAK is a major downstream effector of integrin signaling and is implicated in the formation of the prechondrogenic aggregates.

JAK-STAT signaling is a major cytokine effector pathway critical for the development and function of different immune cell types [ 1, 2].

In this report, we identified autocrine activation of TGF-β3 signaling as a major effector of the phenotypic changes induced by ICN signaling, sufficient to suppress transformation of QNR/v-srcts cells and promote their acquisition of glial differentiation markers, in presence of an active oncoprotein.