Consistent with a major signaling defect, functional and biochemical defects exhibited by CD148-deficient platelets were substantially more severe than those observed in platelets from FcR γ-chain heterozygous-deficient mice, which express a similar reduction in the GPVI-FcR γ-chain complex.
To examine the major signaling defects found in cultured TSC-deficient adipocytes in these tumors, we compared normal human adipose tissue to AML tissue from TSC patients (Figure 6).
As such, major defects in ciliogenesis appear as Hh signalling defects.
Several specific TFs, in addition to playing roles in DNA repair and cell signalling defects, are known to play major roles in CRC.
A number of genetic and signaling defects have been identified.
Therefore, whether RhoGTPase signaling defects are the cause or consequence of PC defects should be the subject of further investigation.
Congenital heart defects are the most common type of major birth defect, and account for the majority of morbidity and mortality related to birth defects.
Importantly, we observed a major thermoregulatory defect in PRLR KO animals at birth, highlighting the physiological importance of PRL signaling in adaptive thermoregulatory responses to cold challenge.
Visual inspection of residual sign images of.cel files using Affy PLM [33] revealed no major geographic defects in microarray signal intensity.
It turns out that the linchpin has a major structural defect: the world's major equity markets tend to become highly correlated during major sell-offs.
