Sentence examples for major signalling cascade from inspiring English sources

The unfolded protein response (UPR) is a major signalling cascade acting in the quality control of protein folding in the endoplasmic reticulum (ER).

The mitogen activated protein kinase (MAPK) pathway, a major signalling cascade involved in the control of cell growth and proliferation, has been indicated to play a role in the intracellular signalling process of breast carcinomas [ 7- 9].

The mitogen-activated protein kinase (MAPK) pathway (including the cascade of RAS, BRAF, MEK1/2, and extracellular-signal-regulated kinase (ERK 1/2 proteins) has emerged as a major signalling cascade, involved in the control of cell growth, proliferation, and migration in majority of the cancers.

These two major signalling cascades regulate the expression of antimicrobial peptides and other immune genes by the fat body after a systemic infection [19].

In Drosophila, several non-catalytic PGRPs function as selective peptidoglycan receptors upstream of the Toll and Imd pathways, the two major signalling cascades regulating the systemic production of antimicrobial peptides.

The PI3K/Akt pathway is one of the major signalling cascades in colon cancers downstream of EGFR (Efferth, 2012).

The UPR involves three major signalling cascades that enable the cell to deal with the build up of misfolded (or unfolded) proteins, which are detected by sensors within the ER [ 30].

The major signalling cascades evoked by LPA are (i) Gq-mediated activation of phospholipase C PLCC) leading to Ca2+ mobilization, (ii) Gαi-mediated inhibition of adenylate cyclase, activation of mitogen-activated protein kinase (MAPK) pathway(s) and protein kinase B (PKB /Akt pathway or (iii) Gα12/13-mediated Gα12/13-mediatedoactivation

Furthermore, activated PKA, a major signaling cascade that mediates the fasting state, induces degradation of SREBP1c by increasing RNF20 expression.

The Wnt/β-catenin pathway is a major signaling cascade in bone biology, playing a key role in bone development and remodeling.

Phosphorylation of the activation loop tyrosines (Y1238/9), a hallmark of kinase activation, and induction of a major signaling cascade downstream of Ron, the Ras-Map kinase pathway, were examined.