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The first major sign of this crackdown came in December 2009.
Now, the plan's success would be a major sign of Mr. Armstrong's fortitude.
This is a major sign of a more relaxed attitude about the one-child policy in place since the seventies.
There was at least one major sign last week that national Republicans are prepared to take the race seriously.
"It's the first major sign of a stand-down we've seen in the smartphone wars," said Christopher V. Carani, a patent lawyer with McAndrews Held & Malloy in Chicago.
After the plan was announced, it appeared that its completion on schedule and without major revision would be a major sign of stability.
The first major sign that low fares will be less available came in late September when United and US Airways said they would shut down their discount operations.
A major sign of problems came in August when Mr. Mortier announced a last-minute bid to become a co-director of the Bayreuth Festival in Germany.
The development was a major sign that the Republican financial establishment was coalescing around Mr. McCain, who has often been at odds with his own party, particularly conservatives.
But if, like many of the world's grape-growers, you want something lighter, the first flush of Botrytis is a major sign of trouble.
Mr Cable was seen in the Treasury yesterday afternoon as the agreement neared completion, the first major sign that a deal on a full coalition had been hammered out.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com