The major modified side chains detected by mass spectrometry were C18, C78, and C108.
The major difference is the side chain orientation of R1687 of Cac that π-stacks with its guanidinium function with Y1372, except for one copy, where it forms a salt-bridge to E1341.
The nature of the side chain has a major effect on solubility and processability of the polymer.
The major drawback of the standard HP side chain model is the bipartiteness of the cubic lattice.
Very long chains are also not recommended as elongation of the side chain has no major effect on the electronic contribution towards activity.
The 1,3,4-oxadiazole side chain is not the major contributor but plays a role in eliciting the observed antifungal activity.
The major steps involved in 4C aliphatic glucosinolate side chain modification are outlined in Figure 1.
Accompanying these major structural changes are a series of local side chain conformational changes that are also important for polymerase function.
At the apex of this plug, the side chain of Lys 91 shows two major populations; in one orientation of the side chain towards Asp 92 and in a less populated orientation toward Glu 40.
Replacement of constraining proline 443 with the larger side chain in leucine results in a major disruption in the beta-sheet in which it resides.
