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"It was a major setback, to this city and its psyche".
Stanley said he considered it a major setback to his efforts in Uganda.
Its failure would be a major setback to progressivism and integration in the Middle East.
The loss of the seat was "a major setback to U.S. diplomacy," the report said.
The cancellation is a major setback to the world title ambitions of both fighters.
The U.S. Supreme Court could be on the verge of issuing a major setback to racial integration efforts.
If taken, it could be a major setback to the Shabab by cutting off their supply line.
However, a loss for Olson and Boies could be a major setback to the movement for marriage equality.
Ed Cox, the director of the IPPR North thinktank, described the announcement as a "major setback to the Northern powerhouse".
A rejection tonight would be a major setback to the mayor and the chancellor, at a most difficult time.
Colon's injury could be a major setback to the Steelers' plans to put a greater emphasis on the run this season.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com