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The phrase "major setback for" is correct and commonly used in written English.
It can be used in various contexts to describe a significant obstacle or hindrance that affects progress or success. Example: The recent economic recession was a major setback for small businesses, causing many to close down and leading to high unemployment rates. In this example, the phrase is used to describe the impact of the economic recession on small businesses. It conveys the idea that the recession had a significant and detrimental effect on the success and survival of these businesses.
Exact(60)
Or a major setback for feminism?
A major setback for Tyndall would be a major setback for her.
Leaving Lincoln Center was a major setback for Mr. Whitehead.
The day wasn't without a major setback for the Marlins.
The court's decision is a major setback for voting rights.
It's a major setback for Republicans on two counts.
Poor performance of anode electrode in MFC is still a major setback for its practical applications.
A major setback for microbial production of aromatics is the high toxicity of the products.
High summer temperature is a major setback for successful greenhouse crop production throughout year.
The economic crisis, however, was a major setback for the neighborhood's development.
Human rights abusers may be rejoicing today, but this is a major setback for their victims".
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com