Sentence examples for major sequence changes from inspiring English sources

Major sequence changes, defined as contiguous amino acid replacements comprising 10 and more residues or 15 and more dispersed amino acid replacements, and were observed in 15 genes (TP0126, TP0127, TP0129, TP0131, TP0132, TP0135, TP0136, TP0266, TP0315, TP0316, TP0433 TP0434, TP0548, TP1030 and TP1031) (see also Tables 2, 3 and 5).

The comparative analysis of the intron 4 sequence between the two genotypes (recessive white or colored chickens) and the published sequence for the Red Jungle Fowl [ 10] revealed three major sequence changes between the recessive white chicken and the Red Jungle Fowl and two major sequence changes between the colored INRA chicken and the Red Jungle Fowl.

Analysis of the repeat unit content of the orangutan elements identified two orangutan specific RU types: the 43 bp Q-type RU that has developed concomitantly with major sequence changes in the SINE-R in the transition from SVAPA_1 (SVA_A) to SVAPA_2 and the 38 bp R-type RU specific to the younger subfamilies SVAPA_7-11 (Additional file 1: Figure S3).

For all 6 genes we confirmed by sequencing that the TE annotated in Col was present in the same genomic location in Ler and Cvi with no major sequences changes except for a few SNPs.

Interestingly, the fast-growing pathogenic strain DAL-1 [41] has a 58 bp insertion in this gene resulting in a frameshift and hence a major protein sequence change in this antigen.

An exon-centric array design that covered the entire genome revealed no major sequence copy number changes relative to the reference DNA.

We observed a complex history shaped by three successive events well separated in time: (i) an ancestral duplication event specific to teleost fishes corresponding to the WGD; (ii) a parallel loss of one duplicated copy (AR-B) in basal Clupeocephala and (iii) a major sequence divergence indicative of a change in functional constraints in the AR-B duplicate of Percomorphs.

Protein structures are generally considered invariant to maintain function (37), but sequence determines structure and sequence changes are the major determinant of evolution (38, 39).

There is a major problem in understanding how extremely subtle sequence changes can lead to profound and often unexpected differences in self-assembly behavior.

The plu1752 5'UTR maintains the four looped out/bulged positions present in ompF 5' UTR major stem loop, albeit there are nucleotide sequence changes in these regions.

In general, the loss or gain of an intron represents a major genetic rearrangement and is a relatively rare event when compared with sequence changes [ 35].