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This indicated, that STIM1 is a major sensor of ER Ca2+ levels during SOCE.
Our data indicate that nestin in conjunction with vimentin determines cytoplasmic accumulation of the glucocorticoid receptor, a major sensor of stress response at the cellular level.
Besides these, a new class of PRRs, the C-type lectin receptor family has also emerged as a major sensor of pathogens.
Recent studies have found that one major sensor of redox signalling at this switch in cellular responses is autophagy.
Adenosine monophosphate-activated protein kinase (AMPK) acts as a major sensor of cellular energy status in cancers and is critically involved in cell sensitivity to anticancer agents.
The major sensor of DSBs is ataxia telangiectasia mutated (ATM) kinase, which is critical for the initial steps of the DNA damage response (DDR).
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Toll-like receptor (TLR) 13 and TLR2 are the major sensors of Gram-positive bacteria in mice.
In addition, key players in fatty acids metabolism (Lpl and Fabp3) proved to be major sensors of SCI induced inactivity and reloading with training.
TRPM8 is a member of the transient receptor potential (TRP) channel family of the melastatin subgroup, which is thought to be a major sensor for a wide range of cold temperatures in the peripheral nervous system [1], [2], [3].
In T cells, CaM is considered as a major sensor and transducer of Ca2+ signals, and among CaM-binding signal traducers are Cn and Ca2+/CaM-stimulated protein kinases II and IV (CaMKII and CsaMKIV) [ 60].
Apple also used the opportunity of a major sensor upgrade on the iPhone X to ditch the home button and switch to a more gesture-heavy user interface on the device.
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