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Although the selected sites in STING may affect the specificity for products with different phosphodiester bonds, we did not detect positively selected sites in or near the cGAS active site, suggesting that the major selective pressure acting on the enzyme was not related to changes in STING ligand specificity.
Antibiotic use for clinical, veterinary and agricultural practices provides the major selective pressure for emergence and persistence of acquired resistance determinants.
In evolutionary and conservation biology, parasitism is often highlighted as a major selective pressure.
The major selective pressure acting on synonymous sites is codon usage bias.
Gene ontology analysis supports the role of diet as a major selective pressure in those highly differentiated islands.
Thus, the major selective pressure seems to have been on the catalytic function of the protein, while other areas of the protein retained flexibility in their functional design.
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Our data are consistent with a model of enhanced viral entry efficiency combined with host milieu as major selective pressures driving episodic selection.
Since the primary function of MHC molecules is to present parasite-derived peptides to T-lymphocytes, it has been argued that parasites and pathogens are major selective pressures acting on the evolution of MHC genes [ 1, 2, 5, 6].
It suggests that the major selective pressures have not been specifically for "meat" or "dairy" traits, but rather for more obvious characteristics like coat color or pattern and overall size.
The European Plague (1345 1750) also appears to have exerted major genetic selective pressure, maybe explaining the high frequency of the CCR5-Δ32 deletion (10%), a protective allele, in the European population (Galvani and Slatkin, 2003; Duncan et al., 2005).
Those traits under strong stabilizing selection may not be genetically canalized and the major source of selective pressure for canalization can result from the benefits gained by buffering the effects of environmental perturbations [ 4, 10].
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