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All patients had severely suppressed CD4 T cells and none of the known B-cell epitopes (listed at the Los Alamos HIV databases) were localized in the V1-V3 regiof of sequences from any of our subjects, arguing against immune control as a major selection factor, although lack of immunity, as found in the SIV model, may provide a selective advantage [54].
My understanding of the translational selection hypothesis is that the major selection factor in protein sequence evolution is the minimization of misfolding burden, which is a combination of the proportion of proteins that need to be refolded or removed and of the actual toxicity to the cell of some of the misfolded variants.
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Abiotic stresses constitute major selection factors that impact the frequency of specific crop segments in subsequent generations [ 27- 29].
Heading date, a crucial factor determining regional and seasonal adaptation in rice (Oryza sativa L ., has been a major selection target in breeding programs.
Fernandinho represents the major selection issue.
The lack of major differences between cohorts may simply reflect who participates in research irrespective of sampling framework rather than selection factors per se.
Researchers say this protective allele is a major evolutionary factor in natural selection against Alzheimer's. .
"This paper reinforces for me and greatly emphasizes the importance of CD33 not just as one factor in Alzheimer's but as a major evolutionary factor in natural selection against Alzheimer's".
Taken as a whole, these findings indicate that modulation of apoptosis may be a major driving factor in the selection of CNAs.
Another major limitation factor is the pre-selection of our obese patients scheduled for minor peripheral surgery.
Moreover, substantial evidence supports that evolution and regulation of transcriptional-regulatory systems are major contributing factor on the variation and selection of biological phenotypes [6].
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