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The phrase "major requirement of" is grammatically correct and can be used in written English.
It is often used to describe a significant or important condition or necessity. Here is an example: "The major requirement of obtaining a pharmacy degree is completing a certain number of clinical rotations."
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"You don't want to basically, what they would determine, insult another country by overnight ceasing the supply of a major requirement of their dietary intake which is meat".
The one major requirement of hiking is open space, and lots of it, a commodity in ever-decreasing supply across the suburbs.
I remember former Sydney Theatre Company artistic directors Cate Blanchett and Andrew Upton telling an audience at Sydney Town Hall a few years ago that the major requirement of a healthy future arts precinct at Walsh Bay is public transport.
Performance optimization as per the desired specifications is a major requirement of analog and mixed signal circuit design process.
Amongst the varieties of non-edible plant oil, Jatropha is the most favorable for biodiesel production as they meet the major requirement of biodiesel standards of USA, Germany and European Standard Organization.
In this respect, the capability of quickly computing two-dimensional layouts of hierarchically clustered networks plays an important role and should be a major requirement of many graph visualization systems.
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WASHINGTON — About one-third of employers subject to major requirements of the new health care law may face tax penalties because they offer health insurance that could be considered unaffordable to some employees, a new study says.
PAGE A10 National STUDY POINTS TO PENALTIES For Employer Health Plans About one-third of employers subject to major requirements of the new health law may face tax penalties because they offer health insurance that could be considered unaffordable to some employees, a new study says.
A high quality factor (Q-factor) is one of the major requirements of high-performance resonators.
Durability and sustainability are two major requirements of the asphaltic pavement structure.
This is mainly because adequate capital is one of the major requirements of starting any meaningful enterprise.
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Since I tried Ludwig back in 2017, I have been constantly using it in both editing and translation. Ever since, I suggest it to my translators at ProSciEditing.

Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com